GLP Pre-clinical Core Facility

Our GLP Pre-clinical Core Facility consists of three laboratories dedicated to in vitro cellular studies of radiotheranostic drugs in multiple cancer cell lines, followed by in vivo evaluation of selected lead candidates in relevant xenografts models. RadioMedix’s core facility has IACUC, OLAW accreditation and expertise in pre-clinical micro-PET imaging, pharmacokinetic studies, biodistribution, toxicity, and efficacy studies of radiodiagnostics and radiotherapeutic agents. RadioMedix’s scientists have regulatory experience in compiling the modules required for eIND and IND clinical studies. We have successfully completed projects funded by NIH NCI Phase I and II grants and contracts.

Benchtop micro-PET Genisys4 

Our Benchtop micro-PET Genisys4 is a high-performance PET imaging system. GENISYS4 enhances image quality, proper animal care, and safety with 1.4mm resolution by using high-resolution detectors, fast electronics, and advanced 3D image reconstruction. The high-performance 64-bit workstation controls the GENISYS4 scanner, accelerates reconstruction of image data, and displays larger reconstructed image volumes. The PET system includes a high-performance workstation that supports the display and analysis of large image volumes. The instrument has an integrated animal prep and handling system for imaging with automated connections to anesthesia and heating. Custom imaging chambers keep the animal warm, anesthetized, and in a reproducible position during prep, uptake, and acquisition. Incorporating animal monitoring with physiological control provides a live link to the animal, ensuring proper animal care throughout the study.

Desktop 2D-SPECT γ-eye

γ-eye is a desktop, 2D scintigraphic camera, capable of imaging a wide range of SPECT isotopes. γ-eye allows whole body, mouse dynamic imaging, thus minimizing the number of animals compared to ex vivo biodistribution studies. The instrument has a very small footprint, being as small as a standard printer and data acquisition and processing is carried out through a laptop. Images are available in real time from the first second post administration, while short frames <1min can be acquired. Time activity curves are easily obtained by the end of the acquisition, minimizing the time needed for post processing and improving experimental planning and decision making. The instrument supports anesthesia and heating, ensuring that the animal is kept warm, anesthetized, and in a reproducible position during prep, uptake, and acquisition.